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This guide—a National Center for Lesbian Rights and ACLU joint publication—identifies laws, court decisions, advocacy tips, and other resources that may be helpful for adult transgender prisoners. Each transgender person’s experience in prison and jail is different, in part because the conditions vary a great deal from one prison to another and change over time. However, the safety and health of every transgender prisoner in the United States is guaranteed by the U.S. Constitution no matter where the prisoner is held. This guide includes sections regarding the Prison Rape Elimination Act, Safety and Protection from Violence, Medical Care, Housing and Administrative Segregation, Searches and Privacy, Safely Preserving/Enforcing Rights, and a list of Helpful Resources.